If you are allergic to fesoterodine; any part of fesoterodine; or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had. If you have any of these health problems: Glaucoma, liver disease, slow clearing of the stomach, or trouble passing urine.
Fesoterodine is a competitive muscarinic receptor antagonist with muscle relaxant and urinary antispasmodic properties. Fesoterodine is rapidly hydrolyzed in vivo into its active metabolite 5-hydroxy methyl tolterodine, which binds and inhibits muscarinic receptors on the bladder detrusor muscle, thereby preventing bladder contractions or spasms caused by acetylcholine.
Fesoterodine is in a class of medications called antimuscarinics. It works by relaxing the bladder muscles to prevent urgent, frequent, or uncontrolled urination. How should this medicine be used? Fesoterodine comes as an extended release (long-acting) tablet to take by mouth.Aprepitant is predicted to increase the exposure to fesoterodine. Manufacturer advises adjust fesoterodine dose with moderate inhibitors of CYP3A4 in hepatic and renal impairment. Severity of interaction: Mild Evidence for interaction: Study. Atazanavir.DETERMINATION OF FESOTERODINE FUMARATE 240 B.V.Rami Reddy et. al ester hydrogen Fumarate. The empirical formula is C30 H41 NO 7 and its molecular weight is 527.66 and the chemical structure of Fesoterodine Fumarate and Impurity-A is shown in (Fig.1). Recently, a stability-indicating liquid chromatography (LC) method was developed and validated.
Efficacy. Fesoterodine has the advantage of allowing more flexible dosage than other muscarinic antagonists. Its tolerability and side effects are similar to other muscarinic antagonists and as a new drug seems unlikely to make great changes in practices of treatment for overactive bladder.
Fesoterodine, a nonselective muscarinic-receptor antagonist, was approved by the US Food and Drug Administration in late 2008 for once daily, oral administration in the treatment of OAB to relieve the symptoms of urinary urge incontinence, urgency, and frequency.
Fesoterodine is a competitive muscarinic receptor antagonist. After oral administration, fesoterodine is rapidly and extensively hydrolyzed by nonspecific esterases to its active metabolite, 5-hydroxymethyl tolterodine, which is responsible for the antimuscarinic activity of fesoterodine.
Draft Guidance on Fesoterodine Fumarate This draft guidance, once finalized, will represent the Food and Drug Administration's (FDA's) current thinking on this topic.
Fesoterodine is a competitive, specific muscarinic receptor antagonist. It is rapidly and extensively hydrolysed by non-specific plasma esterases to the 5-hydroxymethyl derivative, its primary active metabolite, which is the main active pharmacological principle of fesoterodine.
Fesoterodine is used to treat symptoms of an overactive bladder, such as incontinence (loss of bladder control) or a frequent need to urinate. This medicine is available only with your doctor's prescription. This product is available in the following dosage forms.
Fesoterodine may also be used for purposes not listed in this medication guide. NOTICE: This health information was not created by the University of Michigan Health System (UMHS) and may not necessarily reflect specific UMHS practices. For medical advice relating to your personal condition, please consult your doctor.
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Comments: The marketed formulation contains the fumarate compound (PubChem CID 9849808).Fesoterodine is an antimuscarinic prodrug, with the active metabolite being 5-hydroxymethyl tolterodine (5-HMT, PubChem CID 9819382).
Toviaz (fesoterodine) is a good treatment for overactive bladder, especially when exercises and other methods to control it haven't worked. Only recommended after you've tried doing exercises, bladder training, and other changes to your lifestyle.
Side Effects. Drug information provided by: IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.